How accurately reflect creatinine and urea nitrogen with impaired renal function

Serum creatinine

Does Creatinine 1.6 Means Kidney Function is Just Remaining 50%?How creatinine and urea nitrogen with impaired renal function properly reflect it? Serum creatinine and blood urea nitrogen is a marker of impaired renal function, serum creatinine greater than or equal 133 general condition into the renal insufficiency during this period kidney detoxification capacity less than 50%, can not completely exclude the body of a large number of toxins.

Well, specifically, creatinine and urea nitrogen is how it reacted kidney damage? Urea nitrogen and creatinine is a product of the human protein metabolism in normal kidney function can excess urea nitrogen and creatinine excretion to liquid maintain a constant concentration. When subjected to severe renal impairment, the impact of the discharge, urea nitrogen and creatinine will rise. Therefore, creatinine and urea nitrogen test is one way to check kidney function.

Urea nitrogen normal 3.2 to 6.0 mmol / liter. If urea nitrogen> 14.2 mmol / l, called nitrogen mass disorders; eg,> 21.4 mmol / l, called uremia. Creatinine normal 70 to 133 micromoles / liter. Chronic kidney disease appear elevated creatinine and blood urea nitrogen, effective renal function is often more than 60% to 70% suffer. Therefore, creatinine and urea nitrogen detection is not a sensitive indicator of renal function tests. When the measured values of normal and impaired renal function can not be excluded. However, the examination for the diagnosis and prognosis of uremia, are important. Because creatinine and blood urea nitrogen increased the severity of the disease is directly proportional.

Well, creatinine and blood urea nitrogen increased is not a patient in blood urea nitrogen and creatinine increased renal dysfunction certainly it? Can not be absolutely sure. Because many factors can increase blood urea nitrogen. Such as eating a high protein diet, a digestive, heart failure, urinary tract obstruction, severe infections, fever, dehydration and shock, etc., can cause temporary or persistent elevated blood urea nitrogen. Similarly, creatinine also affected some factors, such as eating a lot of meat can creatinine increased, and long-term hunger, pregnancy and muscle atrophy lesions, creatinine content is lower. Therefore, we must conduct a comprehensive clinical analysis of other data, not simply a single laboratory diagnostic hastily.