Chinese herb medicine treat kidney disease by resistanting renal fibrosis

Chinese herb medicine treat CKD by resistanting renal fibrosis 

Cordyceps sinensis is a wonderfully versatile mushroom, in terms of it’s many medicinal applications. Cordyceps sinensis has been applied medicinally for over 2000 years by doctors in China. Western medicine has not always adequately taken Eastern / herbal / traditional medicine into account. The recent discovery of the power of Cordyceps sinensis in the West is the reason for the explosion of popularity of the super mushroom.

Astragalus by inducing hepatocyte growth factor production, inhibit the expression of TGF-βmRNA, prompting the extracellular matrix degradation, played against renal fibrosis, thereby delaying the progression of nephropathy.

Astragalus by inducing 

24h gotu kola can reduce urinary protein excretion, lower blood lipids, creatinine clearance rate increase, inhibit proliferation ECM, down kidney LN, Ⅳ collagen expression FN, and TGF-β, and have prevented glomerulosclerosis.

 gotu kola

Rhubarb and rhubarb extract can effectively reduce the proliferation of renal tubular epithelial cells, reducing its cellular metabolism, thereby reducing the high metabolic state of health nephron damage deposit. At the same time can effectively inhibit human renal fibroblasts proliferation and promote their apoptosis, and both showed a dose-dependent manner.

Rhubarb 

Cordyceps CRF can significantly reduce serum urea nitrogen (BUN), serum creatinine (Scr) levels, inhibiting compensatory glomerular hypertrophy, significantly reduce the pathological changes in the kidneys, especially for tubulointerstitial lesions have significant control effect. Inhibit residual renal tissue between glomerular sclerosis and tubulointerstitial injury in order to delay the progress of CRF.

Cordyceps

Salvia can improve capillary osmotic pressure difference and improve hemodynamic, lower blood pressure, improve the renin - angiotensin - aldosterone system to improve renal function. On fibroblast proliferation inhibition, and can be obtained by high level expression of c-myc protein induces apoptosis. Thereby preventing or reducing scar formation, delaying the occurrence of CRF.

Salvia

Three thousand seven hundred thirty-seven total saponins can inhibit the proliferation of fibroblasts, significantly promote protein overexpression of c-myc, resulting in renal interstitial fibroblast apoptosis, leading to a reduction in the number of fibroblasts to survive in order to play against renal fibrosis among role, but found it and secrete collagen Ⅰ, while significantly reducing the fibroblast expression of β1 integrin, thereby blocking the renal interstitial fibrosis.

Curcuma 

Curcuma can inhibit renal connective tissue proliferation, increased renal blood flow, can significantly reduce the rate of glomerular sclerosis degeneration and transparent, the percentage of protein deposition, and sustainable reduction in urinary protein excretion, thereby improving renal function.

TMP

TMP Chuanxiong inhibit cell proliferation and glomerular ECM generated a lot has been improved creatinine clearance role in improving renal blood flow, against renal fibrosis. In addition, the TMP α- smooth muscle of renal interstitial fibrosis actin (α-SMA) have significantly reduced the role of the muscle fibroblast reduced, indicating that inhibition of renal damage state transformed fibroblasts, for between the formation and development of progressive renal fibrosis also inhibited.

Peach decoction has pro-fibrinolytic effect, and chromogenic peptide substrate method but did not see the promotion, which may be its role in the fibrin clot, increasing the dissolution, rather than the fiber increased protease activity. Can increase the secretion of type I collagenase activity KFB, inhibit proliferation and promote apoptosis, reduce the secretion of collagen type Ⅰ that it plays an important role in the prevention and reversal between renal interstitial fibrosis.

Tripterygium Tripterine can inhibit the generation of proteinuria, increased renal tissue MMP-2, and decreases Ⅰ, Ⅳ collagen, TIMP-2 TGF-β expression and improved histological lesions and improve their survival. Glomerular sclerosis has protective effects.

Ginkgo biloba can reduce the degree of glomerulosclerosis, can reduce internal tubulointerstitial PCNA cells and kidney tissue dry weight units hydroxyproline acid content. And speculated that its mechanism of action in renal interstitial cells may be related to reducing inflammation cells such as monocytes, macrophages in interstitial infiltration and reducing platelet-derived growth factor (PDGF), angiotensin Ⅱ and other cytokines or media mesenchymal cells in the renal tubular expression. Ginkgo biloba tubulointerstitial cell proliferation inhibition can reduce the interstitial collagen or collagen matrix accumulation in the interstitial, thus preventing renal interstitial fibrosis.

Jiaogulan can reduce cholesterol, improve the hypercoagulable state, promote the dissolution of kidney tissue collagen fibers absorb; antagonism of ET and TNF-α, etc., inhibiting mesangial cell proliferation and anti-fibrosis.

Rhodiola reduce α- actin expression by reducing the number of kidney tissue or fibroblasts play a role among anti-renal interstitial fibrosis and renal interstitial injury for better protection.