The cause of diabetic nephropathy

The cause of diabetic nephropathy
The cause of diabetic nephropathy Diabetic nephropathy is defined traditional diagnostics (this is a secondary nephropathy). According to the traditional view, that's right. It is a microvessel complications of diabetes, SPECIAL meant diabetic glomerulosclerosis, one glomerular lesion with damage of blood vessels. In accordance with the most progressive and forward cytological diagnosis of this disease called diabetic glomerular basement membrane.


How is diabetic nephropathy? Due to lack of insulin or resistance to insulin, will increase blood glucose levels and increase blood glucose levels will change the gemotinamiki in the kidney, and appears fittings are high blood pressure, blood glucose, and high content of fat in the blood, and at the same time, lipid peroxidation cause many free oxygen radicals, and even more so, multiply glycosylated hemoglobin lead to rasshirennymu glycation end products. All of these will harm the endothelial cells of the renal glomerulus. And the damage to endothelial cells attract inflammatory cells in the blood and zamochat Simultaneity holiday inflammatory agents. These inflammatory funds will soak in the area of ​​the mesentery, and cause expansion of mesangial cells; foot process fusion of epithelial cells produces a thick drop; shedding of epithelial cells from bazavoy film; bazavoy film thickening and lumen stenosis will hypoxia and ischemia and kidney damage barerskoy function glomerular negative charge, and does not have the power to effectively hold the protein leakage, the patient's condition becomes bad and eventually will glomerulosclerosis. Then in the clinic have a greater creatinine and urea nitrogen. Thanks to this concerning the principles of the disease, we can easily find out the cause of the disease is diabetic glomerular basement membrane disease. The symptom is vyshesleduyuschimi proteinuria and symptoms.