Readme diabetic nephropathy: I'm the most likely deteriorate Diabetic Nephropathy Treatment

Readme diabetic nephropathy: I'm the most likely deteriorate Diabetic Nephropathy Treatment

I, the only one without creatinine legendary 800 you can make a host into existence uremia; I, the legendary most likely deteriorate into uremia kidney disease; I'm diabetic nephropathy.
I grew up very difficult
All can lead to kidney disease uremia, I would be the hardest, "growth", only compared to other kidney disease requiring renal-onset cases can "easily" and "erosion" kidney of the host, and ultimately lead to uremia.
And my "growth" will have a lot of difficulty, I was already in the case of the host with diabetes, due to ignorance and error treatment for their condition, and ultimately worsen the condition of a step by step, the deterioration of diabetic nephropathy.
I of the etiology and pathogenesis is unclear. Now that the Department of multiple factors involved in the joint action of a certain genetic background and some of the risk factors of disease.
1. genetic factors
The proportion of men who have diabetic nephropathy than women; research from the United States found that living in the same environment, African and Mexican-prone diabetic nephropathy compared with whites; the same race, some families prone to diabetic nephropathy, all these are suggests genetic factors. Type 1 diabetes occurs 40% to 50% of microalbuminuria in type 2 diabetes during the observation period is also only 20% to 30% of diabetic nephropathy, are indications that genetic factors may play an important role.
2. renal hemodynamic abnormalities
Early diabetic nephropathy can be observed to the extent of renal hemodynamic abnormalities, manifested as glomerular perfusion and high filtration, renal blood flow and glomerular filtration rate (GFR) increases, and increase protein intake increased after more significant.
3. metabolic disorders caused by high blood sugar
Mechanism of high blood sugar, mainly through the kidney hemodynamics and kidney damage caused by metabolic abnormalities, including metabolic abnormalities cause kidney damage include: ① renal local tissue glucose metabolism, may be formed by glycation end metabolic non-enzymatic glycosylation The product (AGES); ② start polyol pathway; -; ④ has glucosamine pathway metabolism ③ two acyl glycerol start protein kinase c pathway. In addition to the above metabolic abnormalities involved in the early high filtration, more importantly, to promote the glomerular basement membrane (GBM) thickening and accumulation of extracellular matrix; increased glomerular hair
4. Hypertension
Almost any diabetic nephropathy are associated with hypertension, hypertensive nephropathy in type 1 diabetes and microalbuminuria occur in parallel, and then in type 2 diabetic nephropathy often appear before. Blood pressure control is closely related to the development of diabetic nephropathy.
5. metabolism of vasoactive substances
The development and progression of diabetic nephropathy can have a variety of vasoactive substances metabolic abnormalities. Including RAS, endothelin, prostaglandins and growth factor family and other metabolic abnormalities.
My most ferocious illness onset
I was one of the complications of diabetes, vascular disease systemic microcirculation, so I tend to occur at the same time when the merger microangiopathy or other organ systems, such as diabetic retinopathy and peripheral neuropathy. Type 1 diabetes occurs more in the onset of diabetic nephropathy 10 - 15 years, while the occurrence of type 2 diabetic patients with diabetic nephropathy time is short, and the older, more complicated with other underlying diseases.
According to the course and pathophysiology of diabetic nephropathy evolution, Mogensen had suggested to diabetic nephropathy divided into the following five phases:
1. glomerular filtration and renal hypertrophy of
This change is consistent with the initial high blood sugar levels, can be partially alleviated after glycemic control. Issue no histopathological damage.
2. normoalbuminuria period
GFR higher than normal levels. Renal pathology showed thickened GBM, mesangial matrix increase, after exercise, urinary albumin excretion rate (UAE) increased (> 20μg / min), returned to normal after the break. If during this period can be a good control of blood glucose, the patient can long-term stability in the period.
3. The early diabetic nephropathy, also known as "sustained microalbuminuria"
GFR began to fall to normal. Kidney glomerular pathology and nodular lesions in small arteries hyalinization. UAE continues to rise to 20 ~ 200μg / min thereby microalbuminuria. The current patient blood pressure. By ACEI or ARB class of medication, can reduce urinary albumin excretion, delaying the progression of renal disease.
4. Clinical diabetic nephropathy
A typical K-W nodules pathology. Persistent macroalbuminuria (UAE> 200μg / min) or proteinuria greater than 500mg / d, about 30% of patients may present with nephrotic syndrome, GFR continued to decline. Features of the period is not included with urinary protein decreased GFR decline. Once a patient with stage IV disease is often progressive development, if not actively controlled, GFR average monthly decline 1ml / min.
5. End-stage renal failure
GFR <10ml / min. Urine protein due to reduced glomerular sclerosis. Uremic symptoms, requiring dialysis treatment.
Because my particular case, I have been one of a host of the most headache doctor and kidney disease and fear. "War" between us has always been my upper hand, but I know the conventional Western medicine are they not my opponent, only Chinese medicine from the root cause for me to start this kind of "ruthless people" is my biggest rival and flaw.

These "ruthless people" After years of research and practice, have a clear idea of ​​my weakness, at any time may launch "offensive" kill me, how can I do?